Scientific publications

Five million people in the US and Europe suffer from NPH

Normal pressure hydrocephalus (NPH) impacts millions worldwide, yet nearly 80% of cases go undiagnosed or mistaken for other conditions.

Symptoms:

  • Gait disturbance
  • Urinary incontinence
  • Cognitive impairment


A critical step in diagnosing NPH is measuring cerebrospinal fluid (CSF) outflow resistance through a CSF infusion test.

In a National Institute for Health and Clinical Excellence study, 92% of patients with elevated CSF outflow resistance saw improvement after shunting. American Academy of Neurology guidelines confirm the efficacy of this diagnostic pathway.

XP One provides a reliable measurement of CSF outflow resistance to help more clinicians provide their patients with the right diagnosis and access to effective treatment to reverse symptoms.

Managing Idiopathic Normal Pressure Hydrocephalus: Need for a change of Mindset
R. Manet et al. – 2023
As the elderly population continues to increase, iNPH becomes a growing concern in the complex spectrum of neuro-geriatric care, with significant socio-economic implications. The management of iNPH remains largely uncodified, leading to suboptimal care in many cases.

The value of supplemental prognostic tests for the preoperative assessment of idiopathic hydrocephalus
A. Marmarou, Ph.D. et al. – 2005
To date, a single standard for the prognostic evaluation of INPH patients is lacking. However, supplemental tests can increase predictive accuracy for prognosis to greater than 90%.

Prevalence of idiopathic normal pressure hydrocephalus: A prospective, population-based study
J. Andersson et al. – 2019
The prevalence of iNPH was 3.7% among individuals 65 years and older, and more common in the higher age group, 80 years and above. INPH should be increasingly recognized since it is a fairly common condition and an important cause of gait impairment and dementia among the elderly that can be effectively treated by shunt surgery.

Assessment of CSF dynamics using infusion study: tips and tricks
G. Jannelli et al. – 2024
The tap test is the most commonly used prognostic test to confirm the diagnosis but lacks sensitivity. The lumbar infusion study (LIS) appears to be a better option, offering additional information on brain dynamics without increasing morbidity. This technique remains underused.

Hydrocéphalie à pression normale
Samiya Abi Jaoude – 2023
Normal Pressure Hydrocephalus (NPH) is a potentially reversible cause of gait disturbances. However, diagnosing NPH is challenging and requires a combination of clinical, imaging, and CSF hydrodynamic assessments.