Better measure CSF pressure at bedside
X-PRESSURE is a medical device to measure cerebrospinal fluid pressure to better diagnose brain diseases.
Lumbar puncture is usually performed in clinical practice to gain access to cerebrospinal fluid (CSF) to diagnose disorders of the central nervous system.
Lumbar puncture allows to withdraw CSF samples to carry on biological and biochemical analyses. But lumbar puncture allows also to gauge CSF pressure and brain biomechanics at the tip of the needle.
Lumbar CSF pressure is a surrogate marker of intracranial pressure in lateral position. Measuring lumbar CSF pressure is clinically relevant, but performed in routine with a water column, which is an historical procedure. To improve accuracy and reliability, lumbar CSF pressure can be measured electronically, but it requires complex devices.
We developed X-PRESSURE, an accurate, reliable, easy-to-use and connected medical device to facilitate the measurement and analysis of CSF pressure at bedside.
Intracranial hypertension
Pressure of the lumbar cerebrospinal fluid (CSF), was first measured by Quincke in 1891 with a tube connected to a lumbar needle. Pressure was gauged as water column. Normal lumbar CSF pressure is 10 to 25 cm of water (7.2 to 16.8 of mercury).
More than 130 years after Quincke’s seminal publication, lumbar CSF pressure, which is a valid surrogate marker of intracranial pressure, is still measured with a water column worldwide.
Raised intracranial pressure can be due to intracranial haematoma, brain tumour, meningitis due to infection or inflammation, hydrocephalus, arteriovenous malformation, venous sinus thrombosis or intoxication, that might result in severe morbidities such as vision loss, chronic pain or neurological deficit.
Therefore it is important to measure and record reliably CSF pressure with a lumbar needle.
How does it work?
Use case : Hydrocephalus
Use case : Hydrocephalus
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IN A FEW MINUTES, YOU HAVE ALL THE KEY INFORMATION YOU NEED TO MAKE THE RIGHT DIAGNOSIS.
1 single lumbar pressure = 2 investigations
1. CSF biochemistry
2. CSF pressure and detailed intracranial biomechanics by X-PRESSURE
Time saving
Time to perform the examination :
10 to 15 minutes.
Improved precision and reliability of the measurement
Early and reliable diagnosis, to better measure intracranial pressure.
A DEVICE BASED ON 15 YEARS OF R&D AT THE TOULOUSE UNIVERSITY HOSPITAL...
A better diagnosis of hydrocephalus and its treatment improve the autonomy and quality of life of patients.
+1600
patients tested
+800
patients diagnosed
...FOR FAST AND ROBUST DIAGNOSIS
Normal pressure hydrocephalus
Intracranial hypertension
Our partners
They support us
Our team
Pierre-Edouard DE LAMY
CEO and Co-founder
Eric SCHMIDT MD PhD
CSO and Co-founder
Maxime BORETTAZ
CTO
A medical device based on recognized scientific publications and clinical practice
Idiopathic normal pressure
hydrocephalus: historical context
and a contemporary guide
C. Carswell
CSF pressure assessed by lumbar
puncture agrees with
intracranial pressure
N. Lenfeldt, MScEP, BM et al.
Monitoring and interpretation of intracranial pressure
M. Czosnyka, J. D. Pickard
Are intracranial pressure wave amplitudes
measurable through lumbar puncture?
A. Behrens et al.
Lumbar infusion test for the investigation of
normal pressure hydrocephalus
National Institute for Health and Clinical Excellence
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